CARTOGRAPHY
Biosciences

About the start-up

Bridging the worlds of immunology and computation, Cartography will find druggable targets to the cancers whose disease we can’t currently treat and create therapeutics across a range of modalities that are specific enough to only engage tumor cells, broad enough to target every cell in a patient’s tumor, and safe enough to minimize undesired toxicity.

Cartography’s novel comprehensive antigen atlas takes a new point of view on target identification, analyzing cancers through the lens of antigen expression rather than histology or genetic mutations. By revealing the impact that targeting any given antigen may have not just on cancer cells, but also on normal cells throughout the body, this new approach promises to elevate a range of precision immunotherapies to new heights. Cartography is shaping a world in which cancer immunotherapies are designed around and directed toward the safest and most effective targets.

Find out more at www.cartography.bio or follow Cartopraphy Biosciences on LinkedIn.

Project Title

ANTIBODY AND PROTEIN ENGINEERING GROUP

The role involves a mix of computer-based research and hands-on laboratory work, encouraging collaboration with team members and having fun with science.

Project summary

EXAMPLES

1) Protein engineering to optimize the therapeutic properties of antibodies:

Cartography has an active and growing pipeline with multiple projects constantly in development. Each will be focused on a well-defined target. Antibody discovery and engineering/optimization is an integral part of pipeline advancement and an exciting opportunity for scholars to participate in meaningful research with great impact potential.

2) Process and workflow development:

Our group often seeks new strategies for improving our ability to design antibodies in silico and make and test them in the lab utilizing high throughput screening approaches. These are ongoing efforts that comprise a portion of our time. It’s a great opportunity to understand the mechanics of our operations and work with others on creative solutions to improve methods.

3) Concept design and POC:

Cartography is a “modality agnostic” company and we are always searching for the best therapeutic approaches to best leverage the novel targets surfaced from our Atlas. We are constantly innovating and exploring state of the art technology. We look for reasonable or relevant new tech reported in literature or from conferences and test them out in the lab or in silico.

• Gaining experience in the overall drug discovery process, focusing on antibody-based therapeutics.

• Utilization of computational methods to optimize the therapeutic properties of tumor-specific mono- or bispecific antibodies. Techniques may include physics-based molecular modelling as well as machine learning-based approaches.

• Conduct experiments to evaluate the binding affinity and specificity of antibodies (ELISA, BLI, FACS, etc.).

• Learning about and understanding methods for creating stable antibodies suitable for therapeutic applications. Introduction to biophysical techniques for evaluating antibody characteristics.

• Evaluate antibody immunogenicity and humanness using computational tools.

RESponsibility

Learning and leveraging cutting edge antibody engineering techniques, all while developing skills for independently managing a project

About the candidate

Student that wants to learn about antibodies and antibody-based therapeutics. Experience with basic molecular biology, biochemistry, or computational biology techniques is desired.

Prior experience or knowledge of antibodies is a plus.