About the start-up

EpiBiologics is a fast-paced biotechnology company developing therapeutic bispecific antibodies with a novel mechanism of action. Our proprietary EpiTAC platform enables the development of first-in-class and best-in-class targeted therapies that degrade disease driving membrane and extracellular proteins.  This approach can be effective against a wide range of disorders that lack meaningful treatment options today.

The Opportunity

The goal of the project is to gain a mechanistic understanding of extracellular targeted protein degradation. The project will involve the design, generation, characterization, and optimization of multi-specific antibodies capable of degrading disease relevant proteins.

Primary responsibility

• Design monoclonal, bispecific, or multi-specific antibodies.

• Clone, express, and purify antibodies.

• Characterize binding, biophysical properties, and in vitro activity of antibodies.

• Analyze data and report findings to the broader group.

About you

• Proficient at performing wet-lab experiments.

• Able to design and run experiments independently.

• Eager to learn new skills and methods relevant in the antibody development field.

• Clearly report and communicate results.

• A student in the field of protein engineering, pharmaceutical design, biochemistry, molecular biology, structural biology, biophysics or related field is preferred.

Pluses

• Previous research experience designing or producing antibodies.

• Experience in oncology or immunology.

• Protein expression in mammalian or bacterial systems.

• Protein purification by AKTA or gravity columns.

• Protein characterization by SDS-PAGE, western blotting, size exclusion chromatography, thermal melt, or mass spectrometry.

• Antibody binding by BLI, SPR, ELISA, or FACS.

• Phage or yeast display.

• Cell-based assays to assess activity of biologics.