Siolta Therapeutics - project b: Immunology student

Short about the company:

Our mission is to develop microbiome-based live biotherapeutics, as well as companion diagnostics, aimed at the prevention and treatment of inflammatory diseases, beginning with asthma. Siolta Therapeutics is a San Francisco-based startup that was co-founded in late 2016 by Susan Lynch (University of California at San Francisco), Nikole Kimes (Siolta, formerly UCSF) and Samir Kaul (founder, Khosla Ventures). Siolta marries powerful new science with the venture-backed start-up world to realize its vision in a streamlined fashion.

Position summary

Siolta is looking to fill a scientist position on our immunology team. We continue to optimize our lead candidate mixed-species biotherapeutic, as well as develop new pipelines for live biotherapeutic therapies. We are looking for an immunologist/cell biologist to support projects related to preclinical efficacy studies in mouse models of allergy and asthma, mechanism of action studies of peripheral tolerance induction by commensal microbial communities and expansion into new indications of inflammatory diseases.

The position will support analysis of clinical samples of a phase I safety trial and help develop, establish and optimize new models of inflammatory diseases.

Job responsibilities

The research scientist will be responsible for processing of tissue samples and run subsequent analyses on these samples using qPCR, ELISA and multi-parameter flow cytometry. The candidate will culture eukaryotic cells lines and perform various in vitro assays to characterize allergic responses. The scientist will also be responsible for drug development through molecular cloning, protein production and purification, as well as characterization of protein-protein interaction and affinity studies. Finally, she/he will assist in evaluating the therapeutic potential of screened drug candidates in animal models of inflammatory disease.

Required skills

Good communication, organization, and documentation skills required.

Laboratory Skills: Aseptic technique, mammalian cell culture, molecular cloning, PCR, qPCR, mouse handling, ELISA, multi-parameter flow cytometry

Qualifications

B.A. in immunology, molecular biology or related field. Knowledge of and passion for the human gut microbiome a plus.